Cell-Based Assays Posters

A Fully Three‐dimensional Assay for High‐content Analysis of Cell Invasion
Details performance of the Oris™ 3D Embedded Invasion Assay. Shows differential inhibition of 3D invasion vs 2D migration by MMP inhibitor GM6001. Presented at ASCB 2015

The new Atmospheric Control Unit (ACU) for the CLARIOstar® provides versatility in long term cell-based assays from Promega and Platypus
Validates the measurement of fluorescence intensity in the detection zone as a means of quantifying cell migration in Oris™ Pro assays. Presented at SLAS 2015

An Automatable 3-Dimensional Cell Invasion Assay Compatible with High Content Analysis
Validates cell movement through a 3D collagen I matrix in the Oris™ Pro Invasion assay, and demonstrates higher Z’ scores than Boyden/transwell assays. Presented at ASCB 2014 and SLAS 2015

A 3-Dimensional Cell Invasion Assay Compatible with High Content Screening
Details the Oris™ Pro Invasion assay performance for analysis of cell migration and invasion, and demonstrates inhibition of migration and invasion by cytochalasin D. Presented at AACR 2014

Cell Migration Assays from Platypus Technologies (Oris™ and Oris™ Pro) are Digitally Imaged Using the PHERAstar FS from BMG LABTECH
Illustrates the use of a high-end plate reader to quantify Oris™ and Oris™ Pro assays efficiently and accurately. Presented at SLAS 2014

Analysis of Multiple Cell Lines and Varying Collagen Concentrations in a 3-Dimensional Cell Invasion Assay
Illustrates how cell invasion rates vary with collagen I concentration and cell type in the Oris™ Pro Cell Invasion Assay. Also shows how ImageJ can be used to virtualize orthogonal views of invading cells in the 3-dimensional collagen matrix. Presented at FAST 2013

HTS Performance and High-content Analysis of Antimigratory Compound Phenotypes Using the Oris™ Pro 384 Cell Migration Assay
An example of how the Oris™ Pro 384 Cell Migration Assay can be used to screen for compounds that act on cell migration. Presented at AACR 2013

HTS performance and high-content analysis of antimigratory compound phenotypes using the Oris™ Pro 384 Cell Migration Assay
One of three posters illustrating the acquisition of multiparametric data sets using the Oris™ Pro Cell Migration Assay with high-content screening systems. Presented at SLAS 2012

High Content Analysis of a Robust 384-Well Cell Migration Assay
The second of three posters illustrating the acquisition of multiparametric data sets using the Oris™ Pro Cell Migration Assay with high-content screening systems. Presented at CYTO 2011

Oris™ Pro 384 Cell Migration Assays run on IN Cell Analyzer 6000
The third of three posters illustrating the acquisition of multiparametric data sets using the Oris™ Pro Cell Migration Assay with high-content screening systems. Presented at SBS 2011

“Optimizing Robustness of the Membrane-free, Oris™ Cell Migration Assay for High Throughput Screening using the BioTek Synergy™ HT Multi-Mode Microplate Reader.”
Details performance of the Oris™ Cell Migration Assay with different plate coatings and alternative stains. Presented at Lab Automation 2009

“A Novel High Throughput-Compatible Cell Migration Screening Assay using an Acumen eX3.”
Details an approach to Oris™ Cell Migration Assay optimization, and provides an efficient data analysis approach that generates high Z-factors. Presented at Lab Automation 2009

Substrate Dependent Effects of c-Met Inhibitors on HGF-induced Cell Migration
Provides examples of how surface coatings impact aspects of cell physiology in the Oris™ Cell Migration Assay. Presented at ASCB 2008